Hepatocyte Antigen (Hep) Antibody Review

 

 

 

Introduction

• Hep is a relatively specific marker for hepatocellular carcinoma (HCC). PMID: 12170084, PMID: 9796718

• a marker of intestinal metaplasia. PMID: 12826887

Expression

• Hepatocyte monoclonal antibody (Hep) (alternatively Hep Par 1 for Hep paraffin 1) has been reported to stain normal hepatic tissue and hepatocellular carcinoma (HCC) with high specificity. PMID: 12170084

• a hepatocellular antigen mainly expressing in normal and neoplastic hepatic tissues. PMID: 12826887

Applications

 

Immunohistochemistry

• Hep, CEA-Gold 5, CD10, and alpha-fetoprotein immunostains were performed on formalin-fixed, paraffin-embedded tissue sections. Hep immunoreactivity was detected in 88 of 96 cases of HCC (92%), with a cytoplasmic and granular pattern of staining. PMID: 12170084

• immunohistochemical staining against Hepatocyte (Hep) and CD10 antibodies in 75 hepatocellular carcinoma (HCC), 50 cholangiocarcinomas, 49 colorectal adenocarcinomas, and 308 gastric adenocarcinomas by tissue array method. PMID: 14676441