B Cell Markers

 

 

 

B cells are lymphocytes that play a large role in the humoral immune response as opposed to the cell-mediated immune response that is governed by T cells. The abbreviation "B" comes from bursa of Fabricius that is an organ in birds in which avian B cells mature. The principal function of B cells is to make antibodies against soluble antigens. B cells are an essential component of the adaptive immune system.

 

 

 

B220

BLAST-2 (EBVCS)

  • an early cell surface marker of human B cell activation and expressed on both activated and lymphoblastoid cells. PMID: 2984280

Bu-1

  • expressed on B cells as well as on a subset of macrophages. PMID: 2649381

CD19

CD20 (L26)

CD22

CD24

  • B cell differentiation marker. PMID: 7658146, PMID: 7829271

  • a glycosylphosphatidylinositol-anchored cell surface molecule, has been identified as a B-cell marker that is lost during cell maturation. PMID: 7829271

CD27

CD57

CD72

  • expression is not restricted to B lineage cells in mouse strains expressing the CD72(b) allele; instead, a population of T lineage cells in these mice also expresses CD72. PMID: 8995186

CD79a, CD79b

CD86

chB6

  • expressed on chicken B cells throughout most of their development, as well as on some non-lymphoid cells. PMID: 8662088

D8/17

  • a disease-specific B cell marker with a world-wide distribution. PMID: 12030895

FMC7

L26

  • a highly effective pan B cell marker that can be detected in paraffin sections. PMID: 3263805

M17

  • a mouse gene expressed specifically in normal germinal center (GC) B cells. PMID: 15677569

  • germinal center-associated lymphoma (HGAL) gene is the human homolog of M17. PMID: 15677569

MUM-1

Pax-5 (BSAP)

  • an pan-B and pan-pre-B-cell marker. PMID: 12360049

  • a B-cell-specific transcription factor, the expression of which is detectable as early as the pro-B-cell stage and subsequently in all further stages of B-cell development until the plasma cell stage. PMID: 12360049

PC47H

  • a B cell activation marker. PMID: 2474446

  • a unique B-cell differentiation marker for study of B-cell activation and differentiation. PMID: 8258455