Immunohistochemistry (IHC)

Tumor, Disease & Diagnostic Applications

 

 

 

General Applications

Robinson SP, Rijken PF, Howe FA, McSheehy PM, van der Sanden BP, Heerschap A, Stubbs M, van der Kogel AJ, Griffiths JR.

Tumor vascular architecture and function evaluated by non-invasive susceptibility MRI methods and immunohistochemistry.
J Magn Reson Imaging. 2003 Apr;17(4):445-54.
PMID: 12655584 [PubMed - indexed for MEDLINE]

Theon AP, Metzger L, Griffey S.

In situ analysis of cellular proliferation in canine, feline and equine tumors by immunohistochemistry: a comparison of bromodeoxyuridine, proliferating cell nuclear antigen, and interchromatin-associated antigen immunostaining techniques.
J Vet Diagn Invest. 1994 Oct;6(4):453-7.
PMID: 7858025 [PubMed - indexed for MEDLINE]

Pretlow TP, Pretlow TG.

Putative preneoplastic changes identified by enzyme histochemical and immunohistochemical techniques.
J Histochem Cytochem. 1998 May;46(5):577-83. Review.
PMID: 9606105 [PubMed - indexed for MEDLINE]

Mattern J, Volm M.

Prediction of drug resistance in human tumors using immunohistochemical techniques.
Anticancer Res. 1992 Mar-Apr;12(2):413-8.
PMID: 1349793 [PubMed - indexed for MEDLINE]

DeLellis RA, Wolfe HJ.

Contributions of immunohistochemical and molecular biological techniques to endocrine pathology.
J Histochem Cytochem. 1987 Nov;35(11):1347-51. Review.
PMID: 2443560 [PubMed - indexed for MEDLINE]

Linnoila I, Petrusz P.

Immunohistochemical techniques and their applications in the histopathology of the respiratory system.
Environ Health Perspect. 1984 Jun;56:131-48. Review.
PMID: 6090113 [PubMed - indexed for MEDLINE]

Jordan RC, Daniels TE, Greenspan JS, Regezi JA.

Advanced diagnostic methods in oral and maxillofacial pathology. Part II: immunohistochemical and immunofluorescent methods.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Jan;93(1):56-74. Review.
PMID: 11805778 [PubMed - indexed for MEDLINE]

Pozharisskii KM, Leenman EE.

The role of immunohistochemical methods for determining the type of treatment and prognosis of tumoral diseases
Arkh Patol. 2000 Sep-Oct;62(5):3-11. Review. Russian.
PMID: 11076292 [PubMed - indexed for MEDLINE]

Fanelli M, Locopo N, Gattuso D, Gasparini G.

Assessment of tumor vascularization: immunohistochemical and non-invasive methods.
Int J Biol Markers. 1999 Oct-Dec;14(4):218-31. Review.
PMID: 10669950 [PubMed - indexed for MEDLINE]

Schmitt FC, Kimaid PA, Campos PF, Bacchi CE.

The usefulness of immunohistochemical methods for the anatomopathologic diagnosis
Rev Hosp Clin Fac Med Sao Paulo. 1991 Jan-Feb;46(1):26-30. Portuguese.
PMID: 1843001 [PubMed - indexed for MEDLINE]

Persky B, Thomson SP, Meyskens FL Jr, Hendrix MJ.

Methods for evaluating the morphological and immunohistochemical properties of human tumor colonies grown in soft agar.
In Vitro. 1982 Nov;18(11):929-36.
PMID: 6759369 [PubMed - indexed for MEDLINE]

 

Alveolar hydatid disease

Condon J, Rausch RL, Wilson JF.

Application of the avidin-biotin immunohistochemical method for the diagnosis of alveolar hydatid disease from tissue sections.
Trans R Soc Trop Med Hyg. 1988;82(5):731-5.
PMID: 3075360 [PubMed - indexed for MEDLINE]

 

Alzheimer's disease

Vallet PG, Guntern R, Hof PR, Golaz J, Delacourte A, Robakis NK, Bouras C.

A comparative study of histological and immunohistochemical methods for neurofibrillary tangles and senile plaques in Alzheimer's disease.
Acta Neuropathol (Berl). 1992;83(2):170-8.
PMID: 1373017 [PubMed - indexed for MEDLINE]

 

Amyloidosis

Bely M, Apathy A.

Histochemical and immunohistochemical differential diagnosis of amyloidosis--a brief illustrated essay and personal experience with Romhanyi's method.
Amyloid. 2000 Sep;7(3):212-7.
PMID: 11019862 [PubMed - indexed for MEDLINE]

Janssen S, Elema JD, van Rijswijk MH, Limburg PC, Meijer S, Mandema E.

Classification of amyloidosis: immunohistochemistry versus the potassium permanganate method in differentiating AA from AL amyloidosis.
Appl Pathol. 1985;3(1-2):29-38.
PMID: 3915945 [PubMed - indexed for MEDLINE]

 

Asphyxia

Morita M, Tabata N, Ikeda T, Azumi J.

Studies on asphyxia: morphological research for the aid of diagnosis of asphyxia using light and electron microscopy and immunohistochemical methods.
Nihon Hoigaku Zasshi. 1992 Dec;46(6):403-4.
PMID: 1303439 [PubMed - indexed for MEDLINE]

 

Bladder cancer

Vasko J.

Prognosis in bladder cancer. A study of cytometric, morphometric and immunohistochemical techniques.
Scand J Urol Nephrol Suppl. 1994;160:1-73.
PMID: 7529427 [PubMed - indexed for MEDLINE]

 

Bowel disease

Jeziorska M, Haboubi N, Schofield P, Woolley DE.

Distribution and activation of eosinophils in inflammatory bowel disease using an improved immunohistochemical technique.
J Pathol. 2001 Aug;194(4):484-92.
PMID: 11523058 [PubMed - indexed for MEDLINE]

 

Brazilian spotted fever

Rozental T, Eremeeva ME, Paddock CD, Zaki SR, Dasch GA, Lemos ER.

Fatal case of Brazilian spotted fever confirmed by immunohistochemical staining and sequencing methods on fixed tissues.
Ann N Y Acad Sci. 2006 Oct;1078:257-9.
PMID: 17114718 [PubMed - indexed for MEDLINE]

 

Breast Cancer

Chung HC, Kim DL, Koh EH, Kim JH, Roh JK, Min JS, Lee KS, Yang WI, Kim BS, Lee KB.

Expression of prognostic factors (EGFR, ER) by immunohistochemical staining method in male breast cancer.
Yonsei Med J. 1991 Jun;32(2):126-30.
PMID: 1949915 [PubMed - indexed for MEDLINE]

Umemura S, Kurosumi M, Moriya T, Oyama T, Arihiro K, Yamashita H, Umekita Y, Komoike Y, Shimizu C, Fukushima H, Kajiwara H, Akiyama F.

Immunohistochemical evaluation for hormone receptors in breast cancer: a practically useful evaluation system and handling protocol.
Breast Cancer. 2006;13(3):232-5. Review.
PMID: 16929115 [PubMed - indexed for MEDLINE]

Fisher ER, Anderson S, Dean S, Dabbs D, Fisher B, Siderits R, Pritchard J, Pereira T, Geyer C, Wolmark N.

Solving the dilemma of the immunohistochemical and other methods used for scoring estrogen receptor and progesterone receptor in patients with invasive breast carcinoma.
Cancer. 2005 Jan 1;103(1):164-73.
PMID: 15565575 [PubMed - indexed for MEDLINE]

Lukashina MI, Zhukova LG, Glukhova EI, Ozerova OA, Ermilova VD, Bogatyrev VN, Baryshnikov AIu.

Comparison of immunocytochemical and immunohistochemical methods for biomarker detection in breast cancer
Klin Lab Diagn. 2002 Aug;(8):37-41. Russian.
PMID: 12362640 [PubMed - indexed for MEDLINE]

Gallo C, Orlassino R, Demarchi A, Vallero P, Vineis C.

Comparative analysis of various biochemical and immunohistochemical methods for evaluating hormone receptors in breast carcinoma
Pathologica. 2002 Aug;94(4):176-80. Italian.
PMID: 12325415 [PubMed - indexed for MEDLINE]

Albonico G, Querzoli P, Ferretti S, Rinaldi R, Nenci I.

Biological profile of in situ breast cancer investigated by immunohistochemical technique.
Cancer Detect Prev. 1998;22(4):313-8.
PMID: 9674874 [PubMed - indexed for MEDLINE]

Molino A, Micciolo R, Turazza M, Bonetti F, Piubello Q, Corgnati A, Sperotto L, Recaldin E, Spagnolli P, Manfrin E, Bonetti A, Nortilli R, Tomezzoli A, Pollini GP, Modena S, Cetto GL.

Prognostic significance of estrogen receptors in 405 primary breast cancers: a comparison of immunohistochemical and biochemical methods.
Breast Cancer Res Treat. 1997 Sep;45(3):241-9.
PMID: 9386868 [PubMed - indexed for MEDLINE]

Gohring UJ, Scharl A, Thelen U, Ahr A, Crombach G, Titius BR.

Prognostic value of cathepsin D in breast cancer: comparison of immunohistochemical and immunoradiometric detection methods.
J Clin Pathol. 1996 Jan;49(1):57-64.
PMID: 8666688 [PubMed - indexed for MEDLINE]

Siitonen SM, Haapasalo HK, Rantala IS, Helin HJ, Isola JJ.

Comparison of different immunohistochemical methods in the assessment of angiogenesis: lack of prognostic value in a group of 77 selected node-negative breast carcinomas.
Mod Pathol. 1995 Sep;8(7):745-52.
PMID: 8539232 [PubMed - indexed for MEDLINE]

Molino A, Micciolo R, Turazza M, Bonetti F, Piubello Q, Corgnati A, Sperotto L, Martignoni G, Bonetti A, Nortilli R, et al.

Estrogen receptors in 699 primary breast cancers: a comparison of immunohistochemical and biochemical methods.
Breast Cancer Res Treat. 1995 Jun;34(3):221-8.
PMID: 7579486 [PubMed - indexed for MEDLINE]

Ishikawa T, Yamamoto K, Saito Y.

Three dimensional analysis of noninvasive ductal carcinoma of the breast using immunohistochemical staining technique of laminin
Nippon Geka Gakkai Zasshi. 1994 Jul;95(7):458-65. Japanese.
PMID: 8072485 [PubMed - indexed for MEDLINE]

Mink D, Hollaender M, von Tongelen B, Villena-Heinsen C, Schmidt W.

Demonstration of estrogen and progesterone receptors in breast cancers with monoclonal antibodies. Different results with enzyme-immunoassay and immunohistochemical methods.
Eur J Gynaecol Oncol. 1995;16(2):81-91.
PMID: 7641743 [PubMed - indexed for MEDLINE]

Bhoopat L, Chaiwun B, Nimmanahaeminda K, Jiviriyawat Y, Suthijitr M.

Detection of estrogen and progesterone receptor bindings in mammary carcinoma cells: a comparative study using immunohistochemical and biochemical methods.
J Med Assoc Thai. 1991 Apr;74(4):218-23.
PMID: 1719113 [PubMed - indexed for MEDLINE]

Reiner A, Spona J, Reiner G, Schemper M, Kolb R, Kwasny W, Fugger R, Jakesz R, Holzner JH.

Estrogen receptor analysis on biopsies and fine-needle aspirates from human breast carcinoma. Correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies.
Am J Pathol. 1986 Dec;125(3):443-9.
PMID: 3541638 [PubMed - indexed for MEDLINE]

Sforza V, Santopietro R, Lio R, Inaudi P, Landi D, Pasqui L.

Estrogen receptor content in breast cancer: correlation between biochemical and immunohistochemical methods.
Appl Pathol. 1986;4(4):292-6.
PMID: 3300726 [PubMed - indexed for MEDLINE]

Lacombe MJ, Delarue JC, Mouriesse H, Contesso G, Friedman S, Sancho-Garnier H, Travagli JP, May-Levin F.

Human breast tumors: a comparison between the biochemical method of measuring estrogen and progesterone receptors and that of an immunohistochemical method.
Gynecol Oncol. 1989 Feb;32(2):174-9.
PMID: 2910778 [PubMed - indexed for MEDLINE]

van Netten JP, Thornton IG, Carlyle SJ, Brigden ML, Coy P, Goodchild NL, Gallagher S, George EJ.

Multiple microsample analysis of intratumor estrogen receptor distribution in breast cancers by a combined biochemical/immunohistochemical method.
Eur J Cancer Clin Oncol. 1987 Sep;23(9):1337-42.
PMID: 2824208 [PubMed - indexed for MEDLINE]

Charpin C, Martin PM, Lachard A, Jacquemier J, Lavaut MN, Andonian C, Pourreau-Schneider N, Toga M.

Kappa casein, lactalbumin and GCDFP 70 localization in human breast carcinomas: an immunohistochemical study using the avidin-biotin-peroxidase complex method.
Med Oncol Tumor Pharmacother. 1985;2(2):103-12.
PMID: 2997552 [PubMed - indexed for MEDLINE]

Rossi E, Ubiali A, Cadei M, Balzarini P, Valagussa E, Lucini L, Alpi F, Galletti A, Fontana L, Tedoldi C, Grigolato P.

HER-2/neu in breast cancer: a comparative study between histology, immunohistochemistry, and molecular technique (FISH).
Appl Immunohistochem Mol Morphol. 2006 Jun;14(2):127-31.
PMID: 16785778 [PubMed - indexed for MEDLINE]

Weaver DL, Krag DN, Manna EA, Ashikaga T, Waters BL, Harlow SP, Bauer KD, Julian TB.

Detection of occult sentinel lymph node micrometastases by immunohistochemistry in breast cancer. An NSABP protocol B-32 quality assurance study.
Cancer. 2006 Aug 15;107(4):661-7.
PMID: 17024757 [PubMed - indexed for MEDLINE]

Cserni G.

Complete sectioning of axillary sentinel nodes in patients with breast cancer. Analysis of two different step sectioning and immunohistochemistry protocols in 246 patients.
J Clin Pathol. 2002 Dec;55(12):926-31. Review.
PMID: 12461060 [PubMed - indexed for MEDLINE]

 

Bronchial carcinomas

Fresvig A, Qvigstad G, Halvorsen TB, Falkmer S, Waldum HL.

Neuroendocrine differentiation in bronchial carcinomas of classic squamous-cell type: an immunohistochemical study of 29 cases applying the tyramide signal amplification technique.
Appl Immunohistochem Mol Morphol. 2001 Mar;9(1):9-13.
PMID: 11277422 [PubMed - indexed for MEDLINE]

 

Canine distemper

Liang CT, Chueh LL, Pang VF, Zhuo YX, Liang SC, Yu CK, Chiang H, Lee CC, Liu CH.

A non-biotin polymerized horseradish-peroxidase method for the immunohistochemical diagnosis of canine distemper.
J Comp Pathol. 2007 Jan;136(1):57-64. Epub 2007 Jan 26.
PMID: 17258225 [PubMed - in process]

 

Canine leptospirosis

Wild CJ, Greenlee JJ, Bolin CA, Barnett JK, Haake DA, Cheville NE.

An improved immunohistochemical diagnostic technique for canine leptospirosis using antileptospiral antibodies on renal tissue.
J Vet Diagn Invest. 2002 Jan;14(1):20-4.
PMID: 12680639 [PubMed - indexed for MEDLINE]

 

Cerebral ischemic damage and repair

Matsumoto M, Yamamoto K, Homburger HA, Yanagihara T.

Early detection of cerebral ischemic damage and repair process in the gerbil by use of an immunohistochemical technique.
Mayo Clin Proc. 1987 Jun;62(6):460-72.
PMID: 2437412 [PubMed - indexed for MEDLINE]

 

Central nervous system tumors

Rubinstein LJ.

Contribution of immunohistochemical methods to the study of central nervous system tumors
Ann Pathol. 1986;6(3):157-63. French.
PMID: 3535816 [PubMed - indexed for MEDLINE]

 

Cervical mesonephric hyperplasia and mesonephric adenocarcinoma of the uterine cervix

Lang G, Dallenbach-Hellweg G.

The histogenetic origin of cervical mesonephric hyperplasia and mesonephric adenocarcinoma of the uterine cervix studied with immunohistochemical methods.
Int J Gynecol Pathol. 1990;9(2):145-57.
PMID: 1692008 [PubMed - indexed for MEDLINE]

 

Cholangiocarcinoma

Wang X, Zhang J, Chen J.

Result of p53, ki-67 protein expression in cholangiocarcinoma with in situ hybridization and immunohistochemistry methods
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2000 Feb;22(1):57-60. Chinese.
PMID: 12903495 [PubMed - indexed for MEDLINE]

 

Chronic allograft nephropathy

Yehia M, Matheson PJ, Merrilees MJ, Beaumont BW, Pilmore HL.

Predictors of chronic allograft nephropathy from protocol biopsies using histological and immunohistochemical techniques.
Nephrology (Carlton). 2006 Jun;11(3):261-6.
PMID: 16756643 [PubMed - indexed for MEDLINE]

 

Coeliac disease and refractory sprue

Patey-Mariaud De Serre N, Cellier C, Jabri B, Delabesse E, Verkarre V, Roche B, Lavergne A, Briere J, Mauvieux L, Leborgne M, Barbier JP, Modigliani R, Matuchansky C, MacIntyre E, Cerf-Bensussan N, Brousse N.

Distinction between coeliac disease and refractory sprue: a simple immunohistochemical method.
Histopathology. 2000 Jul;37(1):70-7.
PMID: 10931221 [PubMed - indexed for MEDLINE]

 

Colon carcinoma

Takenoue T, Nagawa H, Matsuda K, Fujii S, Nita ME, Hatano K, Kitayama J, Tsuruo T, Muto T.

Relation between thymidylate synthase expression and survival in colon carcinoma, and determination of appropriate application of 5-fluorouracil by immunohistochemical method.
Ann Surg Oncol. 2000 Apr;7(3):193-8.
PMID: 10791849 [PubMed - indexed for MEDLINE]

Muller W, Burgart LJ, Krause-Paulus R, Thibodeau SN, Almeida M, Edmonston TB, Boland CR, Sutter C, Jass JR, Lindblom A, Lubinski J, MacDermot K, Sanders DS, Morreau H, Muller A, Oliani C, Orntoft T, Ponz De Leon M, Rosty C, Rodriguez-Bigas M, Ruschoff J, Ruszkiewicz A, Sabourin J, Salovaara R, Moslein G; ICG-HNPCC (International Collaborative Group).

The reliability of immunohistochemistry as a prescreening method for the diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC)--results of an international collaborative study.
Fam Cancer. 2001;1(2):87-92.
PMID: 14574003 [PubMed - indexed for MEDLINE]

Stone JG, Robertson D, Houlston RS.

Immunohistochemistry for MSH2 and MHL1: a method for identifying mismatch repair deficient colorectal cancer.
J Clin Pathol. 2001 Jun;54(6):484-7. Erratum in: J Clin Pathol 2001 Aug;54(8):656.
PMID: 11376026 [PubMed - indexed for MEDLINE]

 

Colorectal adenoma and colorectal adenocarcinoma

Wang LP, Xing HQ, Cao XX, Yu JY, Zheng JY, Gu WN, Xu ZH.

Functional change of colorectal adenoma and its relation with colorectal adenocarcinoma--application of mucin histochemical and immunohistochemical techniques
Zhonghua Zhong Liu Za Zhi. 1987 Nov;9(6):424-6, 24. Chinese.
PMID: 3452539 [PubMed - indexed for MEDLINE]

Scott IS, Morris LS, Bird K, Davies RJ, Vowler SL, Rushbrook SM, Marshall AE, Laskey RA, Miller R, Arends MJ, Coleman N.

A novel immunohistochemical method to estimate cell-cycle phase distribution in archival tissue: implications for the prediction of outcome in colorectal cancer.
J Pathol. 2003 Oct;201(2):187-97.
PMID: 14517835 [PubMed - indexed for MEDLINE]

 

Corticotropic hypophyseal microadenomas

Duskova J.

Corticotropic hypophyseal microadenomas detected by immunohistochemical methods
Cesk Patol. 1990 May;26(2):80-2. Czech.
PMID: 2164454 [PubMed - indexed for MEDLINE]

 

Diffuse axonal injury

Toupalik P.

Diagnosis of early phase diffuse axonal injury using immunohistochemical methods
Soud Lek. 1998 Nov;43(4):50-4. Czech.
PMID: 9931570 [PubMed - indexed for MEDLINE]

Toupalik P, Stefan J.

Immunohistochemical methods in the diagnosis of diffuse axonal injury
Soud Lek. 1997 Aug;42(3):43-6. Czech.
PMID: 9471734 [PubMed - indexed for MEDLINE]

 

Endometrial carcinoma

Szymanski W, Formaniak J, Szymanski M, Grabiec M.

Neo-angiogenesis in immunohistochemical techniques as a prognostic factor in endometrial carcinoma
Ginekol Pol. 2003 Sep;74(9):885-91. Polish.
PMID: 14674140 [PubMed - indexed for MEDLINE]

Chambers JT, Carcangiu ML, Voynick IM, Schwartz PE.

Immunohistochemical evaluation of estrogen and progesterone receptor content in 183 patients with endometrial carcinoma. Part II: Correlation between biochemical and immunohistochemical methods and survival.
Am J Clin Pathol. 1990 Sep;94(3):255-60.
PMID: 1697730 [PubMed - indexed for MEDLINE]

Mutch DG, Soper JT, Budwit-Novotny DA, Cox EB, Creasman WT, McCarty KS Sr, McCarty KS Jr.

Endometrial adenocarcinoma estrogen receptor content: association of clinicopathologic features with immunohistochemical analysis compared with standard biochemical methods.
Am J Obstet Gynecol. 1987 Oct;157(4 Pt 1):924-31.
PMID: 3314520 [PubMed - indexed for MEDLINE]

 

Equine pythiosis

Brown CC, McClure JJ, Triche P, Crowder C.

Use of immunohistochemical methods for diagnosis of equine pythiosis.
Am J Vet Res. 1988 Nov;49(11):1866-8.
PMID: 3073678 [PubMed - indexed for MEDLINE]

 

Erythroleukemic infiltration of a lymph node

Keifer J, Zaino R, Ballard JO.

Erythroleukemic infiltration of a lymph node: use of hemoglobin immunohistochemical techniques in diagnosis.
Hum Pathol. 1984 Nov;15(11):1090-3.
PMID: 6386660 [PubMed - indexed for MEDLINE]

 

Experimental allergic encephalitis (EAE)

El-Gouhary I, Mohamed A, Suleiman S, Benghuzzi H.

Comparison of the amelioration effects of two enzyme inducers on the inflammatory process of experimental allergic encephalitis (EAE) using immunohistochemical technique.
Biomed Sci Instrum. 2005;41:376-81.
PMID: 15850135 [PubMed - indexed for MEDLINE]

 

Gastric cancer

Wu JF.

The relationship between carcinoembryonic antigen (CEA) expression and histogenesis of gastric cancer (application of immunohistochemical and mucin histochemical techniques)
Zhonghua Zhong Liu Za Zhi. 1992 Jan;14(1):13-6. Chinese.
PMID: 1327687 [PubMed - indexed for MEDLINE]

 

Granulomatosis

Antonovych TT, Sabnis SG, Tuur SM, Sesterhenn IA, Balow JE.

Morphologic differences between polyarteritis and Wegener's granulomatosis using light, electron and immunohistochemical techniques.
Mod Pathol. 1989 Jul;2(4):349-59.
PMID: 2569736 [PubMed - indexed for MEDLINE]

 

Head and neck cancer

Calzolari A, Chiarelli I, Bianchi S, Messerini L, Gallo O, Porfirio B, Mattiuz PL.

Immunohistochemical vs molecular biology methods. Complementary techniques for effective screening of p53 alterations in head and neck cancer.
Am J Clin Pathol. 1997 Jan;107(1):7-11.
PMID: 8980360 [PubMed - indexed for MEDLINE]

Bianchini WA, Altemani AM, Paschoal JR.

Undifferentiated head and neck tumors: the contribution of immunohistochemical technique to differential diagnosis.
Sao Paulo Med J. 2003 Nov 6;121(6):244-7. Epub 2004 Jun 28.
PMID: 14989140 [PubMed - indexed for MEDLINE]

 

Hodgkin's disease

Arici DS, Aker H, Gungor M.

Utility of CD15, CD30 & CD45 in the immunohistochemical diagnosis of Hodgkin's disease by antigen retrieval method.
Indian J Med Res. 1999 Jan;109:33-7.
PMID: 10489740 [PubMed - indexed for MEDLINE]

Vasef MA, Alsabeh R, Medeiros LJ, Weiss LM.

Immunophenotype of Reed-Sternberg and Hodgkin's cells in sequential biopsy specimens of Hodgkin's disease: a paraffin-section immunohistochemical study using the heat-induced epitope retrieval method.
Am J Clin Pathol. 1997 Jul;108(1):54-9.
PMID: 9208978 [PubMed - indexed for MEDLINE]

 

Hypoxia

Donadieu E, Hamdi W, Deveze A, Lucciano M, Lavieille JP, Magnan J, Riva C.

Improved cryosections and specific immunohistochemical methods for detecting hypoxia in mouse and rat cochleae.
Acta Histochem. 2007 Jun 18;109(3):177-184. Epub 2007 Mar 8.
PMID: 17349680 [PubMed - as supplied by publisher]

Samoszuk MK, Walter J, Mechetner E.

Improved immunohistochemical method for detecting hypoxia gradients in mouse tissues and tumors.
J Histochem Cytochem. 2004 Jun;52(6):837-9.
PMID: 15150293 [PubMed - indexed for MEDLINE]

 

Intracranial tuberculoma

Sumi MG, Mathai A, Sheela R, Radhakrishnan NS, Radhakrishnan VV, Indhulekshmy R, Mundayoor S.

Diagnostic utility of polymerase chain reaction and immunohistochemical techniques for the laboratory diagnosis of intracranial tuberculoma.
Clin Neuropathol. 2001 Jul-Aug;20(4):176-80.
PMID: 11495007 [PubMed - indexed for MEDLINE]

 

Intraocular tumors

Kochavi O, Munichor M, Lichtig C, Meyer E.

Immunohistochemical staining techniques of intraocular tumors.
Ann Ophthalmol. 1992 Sep;24(9):347-51.
PMID: 1471823 [PubMed - indexed for MEDLINE]

 

Kasabach-Merritt syndrome

Seo SK, Suh JC, Na GY, Kim IS, Sohn KR.

Kasabach-Merritt syndrome: identification of platelet trapping in a tufted angioma by immunohistochemistry technique using monoclonal antibody to CD61.
Pediatr Dermatol. 1999 Sep-Oct;16(5):392-4.
PMID: 10571842 [PubMed - indexed for MEDLINE]

 

Leiomyosarcoma

Hemmi A, Komiyama A, Ohno S, Fujii Y, Katoh R, Yokoyama A, Kawaoi A.

Poorly differentiated desmin-negative and vimentin-positive leiomyosarcoma of the stomach examined by the immunohistochemical and quick-freezing and deep-etching methods.
Virchows Arch. 1998 Apr;432(4):377-83.
PMID: 9565349 [PubMed - indexed for MEDLINE]

 

Leishmania

Xavier SC, de Andrade HM, Monte SJ, Chiarelli IM, Lima WG, Michalick MS, Tafuri WL, Tafuri WL.

Comparison of paraffin-embedded skin biopsies from different anatomical regions as sampling methods for detection of Leishmania infection in dogs using histological, immunohistochemical and PCR methods.
BMC Vet Res. 2006 Jun 8;2:17.
PMID: 16762067 [PubMed - indexed for MEDLINE]

Tafuri WL, Santos RL, Arantes RM, Goncalves R, de Melo MN, Michalick MS, Tafuri WL.

An alternative immunohistochemical method for detecting Leishmania amastigotes in paraffin-embedded canine tissues.
J Immunol Methods. 2004 Sep;292(1-2):17-23.
PMID: 15350508 [PubMed - indexed for MEDLINE]

 

Leukemia

Chuang SS, Li CY.

Useful panel of antibodies for the classification of acute leukemia by immunohistochemical methods in bone marrow trephine biopsy specimens.
Am J Clin Pathol. 1997 Apr;107(4):410-8.
PMID: 9124209 [PubMed - indexed for MEDLINE]

 

Lung Tumors

Nordgren H, Nilsson S, Runn AC, Ponten J, Bergh J.

Histopathological and immunohistochemical analysis of lung tumors: description of a convenient technique for use with fine needle biopsy.
APMIS. 1989 Feb;97(2):136-42.
PMID: 2645925 [PubMed - indexed for MEDLINE]

 

Lymphoma

van den Oord JJ, de Wolf-Peeters C, O'Connor NT, de Vos R, Tricot G, Desmet VJ.

Nodular T-cell lymphoma. Report of a case studied with morphologic, immunohistochemical, and DNA hybridization techniques.
Arch Pathol Lab Med. 1988 Feb;112(2):133-8.
PMID: 3257382 [PubMed - indexed for MEDLINE]

Mendes S, Dreno B.

Diagnosis of primary cutaneous B-cell lymphoma by immunohistochemical and in situ hybridization methods.
Acta Derm Venereol. 2003;83(3):167-70.
PMID: 12816148 [PubMed - indexed for MEDLINE]

 

Mammary carcinomas

McGinley JN, Knott KK, Thompson HJ.

Semi-automated method of quantifying vasculature of 1-methyl-1-nitrosourea-induced rat mammary carcinomas using immunohistochemical detection.
J Histochem Cytochem. 2002 Feb;50(2):213-22.
PMID: 11799140 [PubMed - indexed for MEDLINE]

 

Mammary gland adenocarcinomas

Nowak M, Madej JA, Dziegiel P, Kanzawa H.

Immunohistochemical identification method of tumour cells in the S phase of mitotic cycle and its usefulness in diagnostics of mammary gland adenocarcinomas in bitches.
Pol J Vet Sci. 2006;9(1):57-62.
PMID: 16573276 [PubMed - indexed for MEDLINE]

 

MDR

Mousseau M.

Methods for diagnosing MDR: immunohistochemistry versus molecular biology
Bull Cancer. 1994 Dec;81 Suppl 2:84s-85s. French.
PMID: 7727866 [PubMed - indexed for MEDLINE]

 

Melanoma

Baisden BL, Askin FB, Lange JR, Westra WH.

HMB-45 immunohistochemical staining of sentinel lymph nodes: a specific method for enhancing detection of micrometastases in patients with melanoma.
Am J Surg Pathol. 2000 Aug;24(8):1140-6.
PMID: 10935655 [PubMed - indexed for MEDLINE]

van der Velde-Zimmermann D, Schipper ME, de Weger RA, Hennipman A, Borel Rinkes IH.

Sentinel node biopsies in melanoma patients: a protocol for accurate, efficient, and cost-effective analysis by preselection for immunohistochemistry on the basis of Tyr-PCR.
Ann Surg Oncol. 2000 Jan-Feb;7(1):51-4.
PMID: 10674449 [PubMed - indexed for MEDLINE]

 

Melanotic neuroectodermal tumor of childhood

Greschnoik A, Gartner HV, Ehrenfeld M, Schwenzer N.

The melanotic neuroectodermal tumor of childhood. Tumor identification with immunohistochemical methods. A case report
Dtsch Zahn Mund Kieferheilkd Zentralbl. 1992;80(2):101-4. German.
PMID: 1322198 [PubMed - indexed for MEDLINE]

 

Melioidosis

Wong KT, Vadivelu J, Puthucheary SD, Tan KL.

An immunohistochemical method for the diagnosis of melioidosis.
Pathology. 1996 May;28(2):188-91.
PMID: 8743829 [PubMed - indexed for MEDLINE]

 

Mesotheliomas

Galateau-Salle F.

Immunohistochemistry of mesotheliomas. Technique and current diagnostic contribution of immunohistochemical markers. General review
Arch Anat Cytol Pathol. 1993;41(5-6):212-22. Review. French.
PMID: 8135582 [PubMed - indexed for MEDLINE]

Friedman MT, Gentile P, Tarectecan A, Fuchs A.

Malignant mesothelioma: immunohistochemistry and DNA ploidy analysis as methods to differentiate mesothelioma from benign reactive mesothelial cell proliferation and adenocarcinoma in pleural and peritoneal effusions.
Arch Pathol Lab Med. 1996 Oct;120(10):959-66.
PMID: 12046609 [PubMed - indexed for MEDLINE]

 

Micro-cancer

Hayashi S, Muguruma N, Bando T, Taoka S, Ito S, Ii K.

Vital immunohistochemical staining for a novel method of diagnosing micro-cancer. Examination of immunohistochemical staining of non-fixed fresh tissue.
J Med Invest. 1999 Aug;46(3-4):178-85.
PMID: 10687313 [PubMed - indexed for MEDLINE]

 

Myasthenia gravis

Zander T, Schwab S, Laufenberg I, Sieb JP.

Immunohistochemical detection of complement factors: a reliable method for the diagnosis of myasthenia gravis
Nervenarzt. 2000 Aug;71(8):666-9. German.
PMID: 10996918 [PubMed - indexed for MEDLINE]

 

Myocardial infarction

Rzepecka-Wozniak E, Konieczna M, Bolechala F.

Myocardial ischemia of the driver as a cause of a traffic road accident. Immunohistochemical C9 staining method in diagnostics of early myocardial infarction
Arch Med Sadowej Kryminol. 2006 Apr-Jun;56(2):110-4. Polish.
PMID: 16970083 [PubMed - indexed for MEDLINE]

 

Myocarditis

Dettmeyer R, Schlamann M, Madea B.

Immunohistochemical techniques improve the diagnosis of myocarditis in cases of suspected sudden infant death syndrome (SIDS).
Forensic Sci Int. 1999 Nov 1;105(2):83-94.
PMID: 10605078 [PubMed - indexed for MEDLINE]

Lin SY, Yao QS, Lin JL, Song YX.

Diagnosis of non-typical myocarditis by applying immunohistochemical method of CD68
Fa Yi Xue Za Zhi. 2001 Nov;17(4):207-8, 211. Chinese.
PMID: 12533871 [PubMed - indexed for MEDLINE]

 

Myoepithelioma of the parotid gland

Tanimura A, Nakamura Y, Nagayama K, Tanaka S, Hachisuka H.

Myoepithelioma of the parotid gland. Report of two cases with immunohistochemical technique for S-100 protein and electron microscopic observation.
Acta Pathol Jpn. 1985 Mar;35(2):409-17.
PMID: 2992228 [PubMed - indexed for MEDLINE]

 

Neoplastic cells

Jimenez FJ, Grichnik JM, Buchanan MD, Clark RE.

Immunohistochemical techniques in Mohs micrographic surgery: their potential use in the detection of neoplastic cells masked by inflammation.
J Am Acad Dermatol. 1995 Jan;32(1):89-94.
PMID: 7529778 [PubMed - indexed for MEDLINE]

 

Olfactory disturbance

Yamagishi M, Hasegawa S, Takahashi S, Nakano Y, Iwanaga T.

Immunohistochemical method for the diagnosis of olfactory disturbance.
Acta Otolaryngol. 1987 Jan-Feb;103(1-2):145-50.
PMID: 3551482 [PubMed - indexed for MEDLINE]

 

Oligodendroglioma

Taddei GL, Arganini L, Raspollini MR, Mennonna P, Vannelli B, Nesi G, Buccoliero AM.

Oligodendroglioma: HMB-45 positivity using catalyzed signal amplification method: an immunohistochemical (HMB-45, CD31, p53, Mib-1) and ultrastructural study.
Appl Immunohistochem Mol Morphol. 2001 Mar;9(1):35-41.
PMID: 11277413 [PubMed - indexed for MEDLINE]

 

Oral carcinomas

Kawasaki M, Uobe K, Tanaka A.

A novel immunohistochemical technique for the detection of human oral carcinomas transplanted in nude mice using mouse monoclonal antibodies.
Histochem Cell Biol. 1997 Mar;107(3):177-82.
PMID: 9105888 [PubMed - indexed for MEDLINE]

 

Ovarian cancer

Gabriel M, Obrebowska A, Spaczynski M.

Bone marrow involvement in ovarian cancer determined by immunohistochemical methods
Gynakol Geburtshilfliche Rundsch. 2000;40(3-4):140-4. German.
PMID: 11326158 [PubMed - indexed for MEDLINE]

Kaufmann O, Kother S, Dietel M.

Use of antibodies against estrogen and progesterone receptors to identify metastatic breast and ovarian carcinomas by conventional immunohistochemical and tyramide signal amplification methods.
Mod Pathol. 1998 Apr;11(4):357-63.
PMID: 9578086 [PubMed - indexed for MEDLINE]

Hereiz HA, Bayoumi FA.

Evaluation of diagnosis of ovarian malignancy using immunohistochemical technique.
J Egypt Public Health Assoc. 1992;67(5-6):697-707.
PMID: 1294690 [PubMed - indexed for MEDLINE]

Scott IS, Heath TM, Morris LS, Rushbrook SM, Bird K, Vowler SL, Arends MJ, Coleman N.

A novel immunohistochemical method for estimating cell cycle phase distribution in ovarian serous neoplasms: implications for the histopathological assessment of paraffin-embedded specimens.
Br J Cancer. 2004 Apr 19;90(8):1583-90.
PMID: 15083189 [PubMed - indexed for MEDLINE]

 

Paragangliomas

Kliewer KE, Wen DR, Cancilla PA, Cochran AJ.

Paragangliomas: assessment of prognosis by histologic, immunohistochemical, and ultrastructural techniques.
Hum Pathol. 1989 Jan;20(1):29-39.
PMID: 2912871 [PubMed - indexed for MEDLINE]

 

Partial ornithine transcarbamylase deficiency

Hayasaka K, Metoki K, Ishiguro S, Kato S, Chiba T, Hirooka M, Kikuchi M, Kurobane I, Narisawa K, Tada K.

Partial ornithine transcarbamylase deficiency in females: diagnosis by an immunohistochemical method.
Eur J Pediatr. 1987 Jul;146(4):370-2.
PMID: 3308467 [PubMed - indexed for MEDLINE]

 

Pheochromocytomas and paragangliomas

Kumaki N, Kajiwara H, Kameyama K, DeLellis RA, Asa SL, Osamura RY, Takami H.

Prediction of malignant behavior of pheochromocytomas and paragangliomas using immunohistochemical techniques.
Endocr Pathol. 2002 Summer;13(2):149-56.
PMID: 12165664 [PubMed - indexed for MEDLINE]

 

Pituitary adenomas

Nieuwenhuyzen Kruseman AC, Bots GT, Lindeman J, Schaberg A.

Use of immunohistochemical and morphologic methods for the identification of human growth hormone-producing pituitary adenomas.
Cancer. 1976 Sep;38(3):1163-70.
PMID: 782686 [PubMed - indexed for MEDLINE]

 

Pleomorphic xanthoastrocytoma

Grant JW, Gallagher PJ.

Pleomorphic xanthoastrocytoma. Immunohistochemical methods for differentiation from fibrous histiocytomas with similar morphology.
Am J Surg Pathol. 1986 May;10(5):336-41.
PMID: 3010749 [PubMed - indexed for MEDLINE]

 

Primary cerebellar haemangioblastoma and metastatic renal carcinoma

Gouldesbrough DR, Bell JE, Gordon A.

Use of immunohistochemical methods in the differential diagnosis between primary cerebellar haemangioblastoma and metastatic renal carcinoma.
J Clin Pathol. 1988 Aug;41(8):861-5.
PMID: 3170772 [PubMed - indexed for MEDLINE]

 

Primary traumatic and subsequent secondary cerebral changes

Toupalik P, Klir P, Bouska I, Chadova L.

Immunohistochemical methods in the differential diagnosis of primary traumatic and subsequent secondary cerebral changes
Soud Lek. 2000 May;45(2):18-21. Czech.
PMID: 10916932 [PubMed - indexed for MEDLINE]

 

Prion diseases

Gonzalo-Pascual I, Cuadrado-Corrales N.

Immunohistochemistry techniques in prion diseases
Rev Neurol. 2000 Jul 16-31;31(2):156-9. Spanish.
PMID: 10951674 [PubMed - indexed for MEDLINE]

 

Prostate gland lesions

Weijman J, Zwart P, Vos JG, Ramaekers FC.

Immunohistochemical method for detecting lesions in the prostate gland of bulls treated with diethylstilbestrol-dipropionate.
Vet Rec. 1996 Nov 23;139(21):515-9.
PMID: 8953692 [PubMed - indexed for MEDLINE]

 

Prostatic tumours

Svanholm H, Horder M.

Clinical application of prostatic markers. I. Classification of prostatic tumours using immunohistochemical techniques.
Scand J Urol Nephrol Suppl. 1988;107:65-70.
PMID: 2453920 [PubMed - indexed for MEDLINE]

Presti B, Weidner N.

Granulomatous prostatitis and poorly differentiated prostate carcinoma. Their distinction with the use of immunohistochemical methods.
Am J Clin Pathol. 1991 Mar;95(3):330-4.
PMID: 1996542 [PubMed - indexed for MEDLINE]

Jobsis AC, De Vries GP, Anholt RR, Sanders GT.

Demonstration of the prostatic origin of metastases: an immunohistochemical method for formalin-fixed embedded tissue.
Cancer. 1978 May;41(5):1788-93.
PMID: 348296 [PubMed - indexed for MEDLINE]

 

Renal cell carcinoma

El-Kott AF, Ismaeil MF, El-Moneim MM, El-Baz MA.

Histogenesis of human renal cell carcinoma by using electron microscopy and immunohistochemical techniques.
Int Urol Nephrol. 2005;37(3):439-45.
PMID: 16307314 [PubMed - indexed for MEDLINE]

 

Schwann-cell tumours

Radhakrishnan VV, Saraswathy A, Radhakrishnan NS, Rout D.

Diagnostic utility of immunohistochemical techniques in intramedullary Schwann-cell tumours.
Indian J Pathol Microbiol. 1993 Jan;36(1):87-91.
PMID: 8354567 [PubMed - indexed for MEDLINE]

 

Skin Tumors

Meister P.

Immunohistochemical methods in the diagnosis and differential diagnosis of mesenchymal skin tumors
Hautarzt. 1986 Oct;37(10):537-46. German.
PMID: 3539874 [PubMed - indexed for MEDLINE]

 

Small cell lung cancer

Segawa Y, Ohnoshi T, Ueoka H, Kimura I.

Neural cell adhesion molecule expression and clinical features in small cell lung cancer: a semi-quantitative immunohistochemical approach using an immunogold-silver staining method.
Acta Med Okayama. 1993 Aug;47(4):281-7.
PMID: 8213222 [PubMed - indexed for MEDLINE]

Stark AM, Hugo HH, Tscheslog H, Maximilian H.

p53, BCL-2 and BAX in non-small cell lung cancer brain metastases: a comparison of real-time RT-PCR, ELISA and immunohistochemical techniques.
Neurol Res. 2006 Dec 5; [Epub ahead of print]
PMID: 17535549 [PubMed - as supplied by publisher]

Bing Z, Adegboyega PA.

Metastasis of small cell carcinoma of lung into an ovarian mucinous neoplasm: immunohistochemistry as a useful ancillary technique for diagnosis and classification of rare tumors.
Appl Immunohistochem Mol Morphol. 2005 Mar;13(1):104-7.
PMID: 15722802 [PubMed - indexed for MEDLINE]

 

Sporotrichosis

Marques ME, Coelho KI, Sotto MN, Bacchi CE.

Comparison between histochemical and immunohistochemical methods for diagnosis of sporotrichosis.
J Clin Pathol. 1992 Dec;45(12):1089-93.
PMID: 1479036 [PubMed - indexed for MEDLINE]

 

Squamous cell carcinoma

Ogawa Y, Nishioka A, Hamada N, Terashima M, Inomata T, Yoshida S, Seguchi H, Kishimoto S.

Changes of mutant-type p53 expression in squamous cell carcinoma of the head and neck during radiation therapy and its clinical significance: comparison of an immunohistochemical method and PCR-SSCP assay.
Oncol Rep. 1998 Sep-Oct;5(5):1053-9.
PMID: 9683807 [PubMed - indexed for MEDLINE]

Ogawa Y, Maeda T, Seguchi H, Inomata T, Yoshida S, Kishimoto S, Saito H.

Application of the immunohistochemical method as a predictive assay in radiotherapy of squamous cell carcinoma of oropharynx and hypopharynx.
Oncology. 1990;47(2):155-9.
PMID: 2314828 [PubMed - indexed for MEDLINE]

Ogawa Y, Inomata T, Maeda T, Seguchi H, Nishioka A, Terashima M, Kishimoto S, Saito H, Hirota S, Osaki T, et al.

Application of the immunohistochemical method as predictive assay in radiotherapy of squamous cell carcinoma
Gan No Rinsho. 1988 Oct;34(13):1799-810. Japanese.
PMID: 3264351 [PubMed - indexed for MEDLINE]

 

Streptococcus pneumoniae

Guarner J, Packard MM, Nolte KB, Paddock CD, Shieh WJ, Tondella ML, McGee L, Zaki SR.

Usefulness of immunohistochemical diagnosis of streptococcus pneumoniae in formalin-fixed, paraffin-embedded specimens compared with culture and gram stain techniques.
Am J Clin Pathol. 2007 Apr;127(4):612-8.
PMID: 17369138 [PubMed - indexed for MEDLINE]

 

Subepidermal bullous diseases

Mutasim DF, Diaz LA.

The relevance of immunohistochemical techniques in the differentiation of subepidermal bullous diseases.
Am J Dermatopathol. 1991 Feb;13(1):77-83. Review.
PMID: 2003652 [PubMed - indexed for MEDLINE]

 

Testicular germ cell tumours

Visfeldt J, Jorgensen N, Muller J, Moller H, Skakkebaek NE.

Testicular germ cell tumours of childhood in Denmark, 1943-1989: incidence and evaluation of histology using immunohistochemical techniques.
J Pathol. 1994 Sep;174(1):39-47.
PMID: 7965402 [PubMed - indexed for MEDLINE]

 

Thyroid lesions

Fukuda T, Kamishima T, Saito T, Itoh S, Suzuki T.

Cytoplasmic biotin-like activity interferes with immunohistochemical analysis of thyroid lesions: a comparison of antigen retrieval methods.
Mod Pathol. 1997 May;10(5):515-9.
PMID: 9160320 [PubMed - indexed for MEDLINE]

 

Trichinellosis

Ben GJ, Malmassari SL, Nunez GG, Costantino SN, Venturiello SM.

Evaluation of an enzymatic immunohistochemical technique in human trichinellosis.
J Helminthol. 1997 Dec;71(4):299-303.
PMID: 9443948 [PubMed - indexed for MEDLINE]

 

Usher syndrome type IIa

Cohn E, Bhattacharya G, Pearsall N, Shendrik I, Kimberling W, Cosgrove D.

Immunohistochemistry and reverse transcriptase-polymerase chain reaction as methods for diagnostic determination of usher syndrome type IIa.
Laryngoscope. 2004 Jul;114(7):1310-4.
PMID: 15235367 [PubMed - indexed for MEDLINE]

 

Warty carcinoma of the uterine cervix

Cho NH, Joo HJ, Ahn HJ, Jung WH, Lee KG.

Detection of human papillomavirus in warty carcinoma of the uterine cervix: comparison of immunohistochemistry, in situ hybridization and in situ polymerase chain reaction methods.
Pathol Res Pract. 1998;194(10):713-20.
PMID: 9820868 [PubMed - indexed for MEDLINE]

 

Whipple's disease

Du Boulay CE.

An immunohistochemical study of Whipple's disease using the immunoperoxidase technique.
Hum Pathol. 1982 Oct;13(10):925-9.
PMID: 6182085 [PubMed - indexed for MEDLINE]

Baisden BL, Lepidi H, Raoult D, Argani P, Yardley JH, Dumler JS.

Diagnosis of Wihipple disease by immunohistochemical analysis: a sensitive and specific method for the detection of Tropheryma whipplei (the Whipple bacillus) in paraffin-embedded tissue.
Am J Clin Pathol. 2002 Nov;118(5):742-8.
PMID: 12428795 [PubMed - indexed for MEDLINE]