Myeloid Cell Markers

 

 

 

One of the two classes of marrow-derived blood cells; includes megakaryocytes, erythrocyte-precursors, mononuclear phagocytes, and all the polymorphonuclear leucocytes. That all these are ultimately derived from one stem cell lineage is shown by the occurrence of the Philadelphia chromosome in these, but not lymphoid cells. Most authors tend, however, to restrict the term 'myeloid' to mononuclear phagocytes and granulocytes and commonly distinguish a separate erythroid lineage.

 

 

 

Arginase-1

  • marker for murine, but not human, alternatively activated myeloid cells. PMID: 15905489

BM-1/BM-2/BM-3/BM-4 (Granulocyte)

  • myeloid cell markers.

C1qR(P)

CD11a/CD18

  • a noncovalently associated heterodimeric receptor expressed exclusively on the surface of lymphocytes and myeloid cells. PMID: 8099450

CD11b/CD11c

CD13

CD14

  • a marker for common, immediate myeloid DC precursors with the ability to differentiate into LC and IDC. PMID: 16959899

  • CD14 receptor is a myeloid cell specific receptor, which plays a role in the recognition of lipopolysaccharides (endotoxins of gram-negative bacteria) and cell stimulation. PMID: 10638686

  • a myeloid cell-specific leucine-rich glycoprotein. PMID: 2472171

  • CD14 surface molecule is predominantly expressed by cells of myeloid origin and regarded as a specific marker for macrophages (M phi). PMID: 9286353

CD15

  • typically a myeloid cell antigen by cytoplasmic staining as compared with cell surface staining. PMID: 9819667

  • a marker for more terminally differentiated myeloid cells in blood. PMID: 15536191

  • react specifically with the human myeloid-lineage-derived cell types in both peripheral blood and bone marrow. PMID: 1362194

  • expressed in normal cells and acute myeloid leukemia (AML) cells. PMID: 1681429

CD18 (beta(2) leukocyte integrin)

  • the common chain of leukocyte integrins, is a novel marker of activated myeloid cells. PMID: 11520808

  • transcriptionally regulated in myeloid cells. PMID: 12485937

CD31

CD33

CD34

CD38

  • a 46-kDa type II transmembrane glycoprotein, is expressed during early stages of differentiation in normal and leukemic myeloid cells. PMID: 9794400, PMID: 9548461

CD43

  • highly expressed in cortical thymocytes, platelets, and myeloid cells of normal peripheral blood, is an excellent marker for myeloid cells. PMID: 14651523

CD123

  • well-established myeloid marker, is expressed on human long-term repopulating cells from cord blood and bone marrow. PMID: 16131573

CD138

  • expressed (heterogeneously) in the hematopoietic stem cell fraction (and not only in pre-B and plasma cells), and that tumors arise in both myeloid and lymphoid lineages. PMID: 16953225

  • anti-syndecan-1/CD138 mAbs in combination with the method described here are a suitable tool for detection of cell surface syndecan molecules in cells originating from progenitor cells that can differentiate in both myeloid and lymphoid cells. PMID: 13677614

CLL-1 (C-Type Lectin-Like Molecule-1)

  • a novel myeloid cell surface marker associated with acute myeloid leukemia. PMID: 15548716

CSC-1

  • a monoclonal antibody specific for a novel primate cell surface marker with distinct biochemical properties on human erythroleukemia and myeloid cell lines. PMID: 12193280

  • preferentially expressed by lymphoid cell lines (e.g., Raji, CEM-SS, Jurkat, and MOLT-3). Although CSC-1 also recognizes some uncommitted myeloid and erythroleukemia cell lines. PMID: 12193280

  • CSC-1 cell surface molecule might be useful as a megakaryocytic or monocytic differentiation marker. PMID: 12193280

F4/80

Glut-3

Elastase

  • a marker for neutrophilic myeloid cells. PMID: 6561228

  • normally synthesized in myeloid precursor cells and stored in azurophil granules. PMID: 2124153

GPIIb-IIIa

  • may serve as a myeloid differentiation antigen and as a key integrin of myeloid precursors. PMID: 9398537

GR-1

Lactoferrin (LF)

  • a non-heme, iron-binding glycoprotein which appears to be a specific biochemical marker of differentiation in several cell types, including myeloid cells. PMID: 833425

Ly49B

Lysozyme

MAC-1

MCS2

  • highly specific myeloid cell marker. PMID: 3138020, PMID: 3159446

  • more sensitive than MY9 to detect blasts of the myeloid lineage due to its most frequent reactivity in the cytoplasm of fixed cells by the immunoperoxidase (IP) technique compared with its membrane expression on cell suspensions by immunofluorescence (IF). PMID: 2901804

MO1(CD11b)

  • myeloid differentiation antigen. PMID: 3501858

  • a glycoprotein heterodimer that is involved in cellular adhesion processes and functions as the C3bi receptor of human myeloid cells. PMID: 2838485

MPO (myeloperoxidase)

  • a heme protein, is a major component of azurophilic granules of neutrophils, and a marker for myeloid cell differentiation. PMID: 2831080

  • a major constituent of primary granules of neutrophilic myeloid cells, is a specific marker for myeloid cells in paraffin sections. Immunohistochemical detection of myeloperoxidase represents a sensitive and highly specific technique for identification of mature and immature myeloid cells in paraffin-embedded tissue. PMID: 1724087

My4

MY7

MY7/MY9

MYADM

  • human myeloid-associated differentiation marker gene. PMID: 12075932

  • a novel hematopoietic-associated marker gene expressed in multipotent progenitor cells and up-regulated during myeloid differentiation. PMID: 10733104

VIM-D5

Ym1

Other Myeloid Cell Markers

  • four surface antigens (MY3, MY4, MY7, and MY8) of human myeloid cells. four surface antigens (MY3, MY4, MY7, and MY8) of human myeloid cells, have been used to study differentiation of normal myeloid cells and malignant cell lines. PMID: 6945311